Amelogenesis Imperfecta (Samoyed Type)

General Information: Amelogenesis Imperfecta (Samoyed Type) is an inherited dental disorder that affects Samoyeds, leading to abnormal or severely discolored teeth with irregular surfaces. While the deciduous (puppy) teeth of affected dogs appear normal, the abnormalities become evident when the adult teeth erupt. These teeth often have a blunted appearance with increased spacing due to a thinner enamel layer. This condition predisposes the dogs to various dental issues, including advanced periodontal disease, bad breath, and a higher likelihood of tooth loss due to severe abrasions, fractures, and root infections. The compromised enamel makes the teeth more susceptible to wear and bacterial infection, necessitating diligent dental care to maintain the health and comfort of the affected dogs.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for the SLC24A4 gene is crucial for identifying carriers of the mutated variant responsible for Amelogenesis Imperfecta (Samoyed Type) in dogs. This condition is inherited in an autosomal recessive manner, meaning a dog must inherit two copies of the mutated gene, one from each parent, to develop the disease. Carrier dogs, having only one copy of the mutation, typically do not show symptoms but can pass this variant to their offspring. When two carriers are bred, each puppy has a 25% chance of developing Amelogenesis Imperfecta and a 50% chance of being a carrier. Genetic testing is vital for responsible breeding practices to avoid breeding two carriers, thereby reducing the risk of producing puppies with this dental disorder. By identifying carriers and making informed breeding decisions, breeders can help eliminate this condition from dog populations, promoting healthier and more resilient future generations. While genetic testing for the SLC24A4 genetic variant reduces the risk of Amelogenesis Imperfecta, it is important to remember that other genetic or environmental factors may still contribute to similar dental conditions, necessitating comprehensive genetic screening and careful management.