Dog Health Traits: Complete Guide to Diseases, Symptoms & More

Abortion (embryonic lethality), BTBD17-related

Abortion (embryonic lethality) is a rare genetic disorder caused by mutations in the BTBD17 gene, leading to early pregnancy loss due to impaired fetal development.Learn More

Acral Mutilation Syndrome

Acral Mutilation Syndrome (AMS) is an inherited neurological disease in dogs, characterized by insensitivity to pain in the lower limbs, leading to self-mutilation.Learn More

Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome (ARDS) in dogs is a severe, life-threatening condition predominantly seen in breeds such as Dalmatians, characterized by rapid onset of severe lung inflammation and respiratory failure.Learn More

Adult Onset Deafness Border Collie (Linkage Association Test)

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Adult Paroxysmal Dyskinesia

Adult Paroxysmal Dyskinesia (APD) is an inherited neurological disorder characterized by intermittent, uncontrollable episodes of muscle contractions affecting primarily the limbs in dogs.Learn More

Adaptation to high-altitude hypoxia

EPAS1 mediates adaptation to high-altitude hypoxia by regulating the body's response to low oxygen levels, enhancing oxygen delivery and cellular function in hypoxic environments.Learn More

Afibrinogenemia (Dachshund Type)

Afibrinogenemia (AFG) (Dachshund Type) is an inherited bleeding disorder in dogs caused by a deficiency in the essential blood-clotting protein fibrinogen.Learn More

Alaskan Husky Encephalopathy

Alaskan Husky Encephalopathy (AHE) is a genetic neurological disorder in Alaskan Huskies causing severe brain damage due to impaired thiamine transport, leading to progressive neurological symptoms and often resulting in early euthanasia.Learn More

Alaskan Malamute Polyneuropathy

Alaskan Malamute Polyneuropathy (AMPN) is a debilitating, inherited neuromuscular disorder specific to Alaskan Malamutes. Learn More

Alexander Disease (Labrador Retriever Type)

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Amelogenesis imperfecta in Akitas

Amelogenesis imperfecta in Akitas due to ACP4 mutations results in defective enamel formation, leading to discolored, brittle teeth and increased dental sensitivity.Learn More

Amelogenesis Imperfecta (Italian Greyhound Type)

Amelogenesis Imperfecta (Italian Greyhound type) is an inherited dental disorder in Italian Greyhounds, characterized by misshaped teeth with rough, irregular surfaces and gray or brown spots due to defective enamel, although affected dogs are not at increased risk for periodontal disease. Learn More

Amelogenesis Imperfecta (Parson Russell Terrier Type)

Amelogenesis Imperfecta (Parson Russell Terrier Type) is an inherited dental disorder in dogs, characterized by abnormal or discolored teeth with irregular surfaces, and increased spacing between teeth due to enamel thinning, leading to a higher risk of dental disease and tooth loss. Learn More

Amelogenesis Imperfecta (Samoyed Type)

Amelogenesis Imperfecta (Samoyed Type) is a genetic dental disorder in dogs causing abnormal, discolored, and fragile teeth, leading to increased susceptibility to dental diseases and tooth loss.Learn More

Autosomal Recessive Neuronal Degeneration

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Bald Thigh Syndrome

Bald thigh syndrome is a common hair loss disorder in sighthounds causing the thigh to loose hair folliclesLearn More

Behavior Propensity in Belgian Malinois

Behavior Propensity in Belgian MalinoisLearn More

Benign Familial Juvenile Epilepsy

Benign Familial Juvenile Epilepsy (BFJE) is a genetic condition in Lagotto Romagnolo dogs, characterized by transient seizures starting in puppyhood and resolving by four months of age. Learn More

Bernard-Soulier Syndrome

Bernard-Soulier Syndrome (BSS) is an inherited bleeding disorder in dogs characterized by prolonged bleeding, the formation of hemotomas and large clots. Learn More

Brachycephaly

Brachycephaly (BR) is a condition in dogs characterized by a shortened skull and snout, commonly seen in breeds like pugs and bulldogs.Learn More

β-Mannosidosis

β-Mannosidosis is a rare inherited metabolic disorder caused by mutations in the MANBA gene, leading to a deficiency in the enzyme beta-mannosidase, which results in the accumulation of mannose-containing compounds and causes neurological and systemic symptoms.Learn More

Cardiac arrhythmia

Cardiac arrhythmia due to QIL1 is a rare genetic condition caused by mutations in the QIL1 gene, leading to disturbances in the heart's electrical conduction system.Learn More

Canine Congenital Stationary Night Blindness

Canine Congenital Stationary Night BlindnessLearn More

Canine Leukocyte Adhesion Deficiency, Type I

Canine Leukocyte Adhesion Deficiency, Type I (CLAD1) is a severe inherited immunodeficiency disorder characterized by dysfunctional white blood cells and recurrent infections.Learn More

Canine Multiple System Degeneration (Chinese Crested Type)

Canine Multiple System Degeneration (CMSD) (Chinese Crested Type) is a progressive inherited neurological disease causing severe motor impairments in Chinese Crested dogs.Learn More

Canine Multiple System Degeneration (Kerry Blue Terrier Type)

Canine Multiple System Degeneration (CMSD) (Kerry Blue Terrier Type) is a progressive inherited neurological disorder that significantly impairs motor functions in Kerry Blue Terriers.Learn More

Canine Progressive Retinal Atrophy

Canine Progressive Retinal Atrophy (PRA) due to BBS4 is a genetic disorder in dogs caused by mutations in the BBS4 gene, leading to progressive degeneration of the retina and eventual blindness.Learn More

Canine Scott Syndrome

Canine Scott Syndrome (CSS) is a genetic blood clotting disorder in dogs that causes excessive bleeding due to defective platelets.Learn More

Cardiomyopathy and Juvenile Mortality

Cardiomyopathy and Juvenile Mortality (CJM) is an inherited disorder in dogs characterized by early heart failure and high mortality rates in puppies.Learn More

Centronuclear Myopathy

Centronuclear Myopathy (CNM) is an inherited muscle disorder in Labrador Retrievers characterized by progressive muscle weakness and degeneration.Learn More

Catalase Deficiency

Catalase Deficiency (CD) is a genetic disorder in dogs that impairs the enzyme catalase, increasing the risk of oral ulceration and gangrene.Learn More

Centronuclear Myopathy (Labrador Retriever Type)

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Cerebellar Ataxia (CA) (Spinone Italiano Type)

Cerebellar Ataxia (CA - Spinone Italiano Type) is an inherited neurological disorder causing incoordination and loss of balance in affected dogs.Learn More

Cerebellar Ataxia (Finnish Hound Type)

Cerebellar Ataxia (CA) (Finnish Hound Type) is a debilitating, inherited neurological disorder characterized by early-onset cerebellar degeneration, leading to severe movement control issues in affected dogs.Learn More

Cerebellar Ataxia (RALGAPA1)

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Cerebellar Ataxia (SELENOP)

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Cerebellar Ataxia 1 (Belgian Shepherd Type)

Cerebellar Ataxia 1 (SDCA1) is a devastating, inherited neurological disorder in Belgian Shepherds characterized by severe motor coordination issues and early onset. Learn More

Cerebellar Ataxia 2 (Belgian Shepherd Type)

Cerebellar Ataxia 2 (SDCA2) Belgian Shepherd Type) is a progressive, early-onset neurological disease in dogs, characterized by difficulties in regulating potassium in the central nervous system, resulting in impaired motor coordination, tremors, seizures, and typically leading to a poor prognosis due to the severity and rapid progression of symptoms.Learn More

Cerebellar Cortical Degeneration

Cerebellar Cortical Degeneration (CCD) is a genetic neurological disorder discovered in Vizslas, leading to progressive loss of coordination and severe mobility issues, often resulting in euthanasia.Learn More

Cerebellar Degeneration

Cerebellar Degeneration (CA) is an inherited neurological disorder in dogs, characterized by the progressive loss of cerebellar function leading to severe movement and coordination difficulties. Learn More

Cerebral Dysfunction (Friesian Stabyhoun Type)

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Chondrodysplasia (Karelian Bear Dog and Norwegian Elkhound Type)

Chondrodysplasia (dwarfism) in Karelian Bear Dogs and Norwegian Elkhounds is a genetic disorder marked by malformed cartilage and bone development leading to dwarfism. Learn More

Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth Disease (CMT) is a hereditary neurological disorder characterized by motor and sensory neuropathies in dogs.Learn More

Chondrodystrophy (CDDY and IVDD Risk) with or without Chondrodysplasia (CDPA)

Chondrodystrophy (CDDY and IVDD Risk) with or without Chondrodysplasia (CDPA) is a genetic condition in dogs that leads to shortened limbs and an increased risk of intervertebral disc disease.Learn More

Cleft Palate (DLX6-related)

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Coagulation Factor VII Deficiency

Coagulation Factor VII Deficiency (FVII) is an inherited bleeding disorder in dogs caused by a deficiency of factor VII, essential for normal blood clotting.Learn More

Cleft Palate and Syndactyly (Nova Scotia Duck Tolling Retriever Type)

Cleft Palate and Syndactyly (Nova Scotia Duck Tolling Retriever Type) is an inherited developmental condition in dogs, characterized by facial deformities including clefts in the upper lip and palate, along with fused toes.Learn More

Collie Eye Anomaly

Collie Eye Anomaly (CEA) is a congenital, inherited eye disorder that affects the development of the choroid, a vital ocular layer in several dog breeds.Learn More

Complement 3 Deficiency

Complement 3 Deficiency is an inherited immune disorder in dogs, particularly affecting the Brittany breed, causing susceptibility to recurrent bacterial infections and early-onset kidney disease.Learn More

Cone Degeneration

Cone Degeneration is an inherited eye disorder in dogs that causes day blindness and light sensitivity due to the degeneration of cone photoreceptor cells.
This disease is also known as Achromatopsia 3 (Day Blindness)Learn More

Gallbladder Mucoceles

Gallbladder Mucoceles is a serious condition in dogs where the gallbladder becomes filled with thick, mucus-like bile, potentially leading to life-threatening complications.Learn More

Glanzmann's Thrombasthenia (Great Pyrenees Type)

Glanzmann's Thrombasthenia (GT) (Great Pyrenees Type) is a genetic disorder in dogs characterized by impaired platelet function leading to abnormal bleeding.Learn More

Glanzmann's Thrombasthenia (Mixed breed)

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Glaucoma (Border Collie Type)

Glaucoma (GLAU) in Border Collies is an inherited eye condition characterized by increased intraocular pressure leading to vision loss.Learn More

Glanzmann's Thrombasthenia (Otterhound Type)

Glanzmann's Thrombasthenia (GT) (Otterhound Type) is a genetic disorder in dogs characterized by impaired platelet function resulting in excessive bleeding. Learn More

Globoid Cell Leukodystrophy (Irish Setter Type)

Globoid Cell Leukodystrophy (GLD) (Irish Setter Type) is an inherited lysosomal storage disorder in dogs, characterized by progressive muscle weakness and uncoordinated movement.Learn More

Globoid Cell Leukodystrophy (Terrier Type)

Globoid Cell Leukodystrophy (GCL) is a rare and fatal genetic disorder in dogs that impairs myelin production, leading to severe neuromuscular symptoms.Learn More

Glycogen Storage Disease Ia

Glycogen Storage Disease Ia (GSD1a) is an inherited metabolic disorder in dogs characterized by the inability to break down glycogen, leading to its accumulation in various organs. Learn More

Glycogen Storage Disease IIIa

Glycogen Storage Disease IIIa is an inherited metabolic disorder affecting breeds like Curly-Coated Retrievers, caused by insufficient enzymes to break down glycogen, leading to its accumulation in the liver and muscles and resulting in symptoms such as exercise intolerance, lethargy, and liver enlargement, typically presenting between one and two years of age.Learn More

Glycogen Storage Disease VII (Wachtelhund Type)

Glycogen Storage Disease VII (GSD VII), also known as Phosphofructokinase (PFK) deficiency in the Wachtelhund, is an inherited metabolic disorder that impairs energy production in red blood cells and muscles. Learn More

Glycogen Storage Disease VII, PFK Deficiency

Glycogen Storage Disease VII (GSD VII), also known as Phosphofructokinase (PFK) Deficiency, is a genetic disorder in dogs that leads to severe energy production issues and chronic hemolytic anemia. Learn More

GM1 Gangliosidosis (Alaskan Husky Type)

GM1 Gangliosidosis (GM1) (Alaskan Husky Type) is an inherited lysosomal storage disorder in dogs, characterized by neurological symptoms and rapid disease progression, leading to early death. Learn More

GM1 Gangliosidosis (Portuguese Water Dog Type)

GM1 Gangliosidosis (GM1) (Portuguese Water Dog Type) is an inherited lysosomal storage disorder in dogs, characterized by neurological symptoms and rapid disease progression, leading to early death.Learn More

GM1 Gangliosidosis (Shiba Inu Type)

GM1 Gangliosidosis (GM1) (Shiba Inu Type) is an inherited lysosomal storage disorder in dogs, characterized by neurological symptoms and rapid disease progression leading to early death.Learn More

GM2 Gangliosidosis (Japanese Chin Type)

GM2 Gangliosidosis (GM2) (Japanese Chin Type) is an inherited lysosomal storage disorder in dogs, characterized by a deficiency in the enzyme hexosaminidase A, leading to severe neurological symptoms and early death.Learn More

GM2 Gangliosidosis (Poodle Type)

GM2 Gangliosidosis (?GM2) (Poodle Type) is an inherited lysosomal storage disorder in dogs, characterized by a deficiency in the enzyme hexosaminidase B, leading to severe neurological symptoms and early death.Learn More

GM2 Gangliosidosis (Shiba Inu Type)

GM2 Gangliosidosis (GM2) (Shiba Inu Type) is an inherited lysosomal storage disorder in dogs, characterized by a deficiency in the enzyme hexosaminidase B, leading to severe neurological symptoms and early death.Learn More

Greyhound Polyneuropathy

Greyhound Polyneuropathy (GP) is a debilitating, inherited neurologic condition specifically found in Greyhounds.Learn More

Hemophilia A (Boxer Type)

Hemophilia A (Boxer Type) is an inherited bleeding disorder in dogs caused by a deficiency of coagulation factor VIII, essential for normal blood clotting.Learn More

Hemophilia A (German Shepherd Dog, Type 1)

Hemophilia A (German Shepherd Dog, Type 1) is an inherited bleeding disorder in dogs caused by a deficiency of coagulation factor VIII, necessary for normal blood clotting.Learn More

Hemophilia A (German Shepherd Dog, Type 2)

Hemophilia A (German Shepherd Dog, Type 2) is an inherited bleeding disorder caused by a deficiency of coagulation factor VIII, essential for normal blood clotting.Learn More

Hemophilia A (Havanese Type)

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Hemophilia A (Old English Sheepdog Type)

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Hemophilia A (Rhodesian Ridgeback Type)

Hemophilia A (Rhodesian Ridgeback Type) is an inherited bleeding disorder in dogs caused by a deficiency of coagulation factor VIII, essential for normal blood clotting.Learn More

Hemophilia B (Airedale Terrier Type)

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Hemophilia B (Cairn Terrier Type)

Hemophilia B (Cairn Terrier Type) is an inherited bleeding disorder in dogs caused by a deficiency of coagulation factor IX, essential for normal blood clotting.Learn More

Hemophilia B (Lhasa Apso Type)

Hemophilia B (Lhasa Apso Type) is an inherited bleeding disorder in dogs caused by a deficiency of coagulation factor IX, essential for normal blood clotting. Learn More

Hemophilia B (Rhodesian Ridgeback Type)

Hemophilia B (Rhodesian Ridgeback Type) is an inherited bleeding disorder in dogs caused by a deficiency of coagulation factor IX, crucial for normal blood clotting.Learn More

Hereditary Ataxia (Australian Shepherd Type)

Hereditary Ataxia (HA) (Australian Shepherd Type) is an inherited neurological disorder that progressively impairs motor coordination in young dogs.Learn More

Hereditary Ataxia (Belgian Malinois Type)

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Hereditary Ataxia (Norwegian Buhund type)

Ataxia in Norwegian Buhunds is a genetic neurodegenerative disorder marked by progressive movement and coordination difficulties due to cerebellar dysfunction. Learn More

Hereditary Cataracts

Hereditary Cataracts (HC) is a genetic eye condition in dogs that leads to the progressive clouding of the lens, ultimately causing blindness.Learn More

Hereditary Cataracts (Wirehaired Pointing Griffon Type)

Hereditary Cataracts (Wirehaired Pointing Griffon Type) is an inherited eye condition affecting Wirehaired Pointing Griffon dogs, characterized by lens opacities leading to blurry vision and visual deficits, typically appearing within weeks to months after birth and potentially worsening with age. Learn More

Hereditary Footpad Hyperkeratosis (Rottweiler Type)

Hereditary Footpad Hyperkeratosis (Rottweiler Type) is an inherited autosomal recessive disorder in Rottweilers, characterized by hard, thickened footpads that develop deep cracks, leading to pain, infections, and lameness, and often managed with regular footpad trimmings and treatment for skin infections. Learn More

Hereditary Footpad Hyperkeratosis (Irish Terrier and Kromfohrländer type)

Hereditary Footpad Hyperkeratosis (HFH) (Irish Terrier and Kromfohrländer type) is an inherited disease in dogs that causes hard, thickened footpads. Learn More

Hereditary Nasal Parakeratosis (Greyhound Type)

Hereditary Nasal Parakeratosis (HNP) in Greyhounds is a genetic condition that causes dry, rough, and crusty lesions on the nose, starting from a young age.Learn More

Hereditary Nasal Parakeratosis (Labrador Retriever Type)

Hereditary Nasal Parakeratosis (HNP) in Labrador Retrievers is a genetic condition causing dry, crusty, and sometimes painful nasal lesions.Learn More

Hereditary Nephritis (Samoyed Type)

Hereditary Nephritis (HN) (Samoyed Type) is an inherited kidney disorder that causes progressive kidney failure, primarily in male Samoyeds.Learn More

Hereditary Vitamin D-Resistant Rickets Type II

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Hypomyelination (Weimaraner Type)

Hypomyelination (HYM) (Weimaraner Type) is an inherited neurological disorder in dogs characterized by generalized tremors starting between 1 to 3 weeks of age.Learn More

Hyperuricosuria

Hyperuricosuria is an inherited condition in dogs that leads to the formation of urinary stones due to elevated levels of uric acid in the urine, causing frequent urinary issues and potential blockages.Learn More

Hypophosphatasia

Hypophosphatasia (HPP) is a metabolic bone disease characterized by defective skeletal mineralizationLearn More

Ichthyosis (American Bulldog Type)

Ichthyosis (ICH) in American Bulldogs is an inherited skin disorder characterized by severe, flaky, and scaly skin manifesting from a young age.Learn More

Ichthyosis (Golden Retriever Type 1)

Ichthyosis (ICH-1) (Golden Retriever Type 1) is an inherited skin disorder characterized by persistent flaky skin and potential for secondary infections.Learn More

Ichthyosis (Golden Retriever Type 2)

Ichthyosis (Golden Retriever Type 2) is an inherited skin disorder in dogs, typically appearing before one year of age, causing flaky skin that progresses to thick, scaly patches, often with a grayish hue.Learn More

Ichthyosis (Great Dane Type)

Ichthyosis (Great Dane Type) is an inherited skin disorder in Great Danes and related breeds, causing severe skin thickening, scaling, and risk of secondary infections, often leading to euthanasia due to poor quality of life.Learn More

Ichthyosis (Jack Russell Terrier Type)

Ichthyosis in Jack Russell Terriers is a genetic skin disorder characterized by widespread, parchment-like scaling, most noticeable on non-hairy areas of the body.Learn More

Ichthyosis (Pembroke Welsh Corgi Type)

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Inflammatory Myopathy (Shepherd Type)

Inflammatory Myopathy (Shepherd Type) is a genetic muscle disorder in Dutch Shepherds causing progressive muscle weakness and deterioration, often leading to euthanasia by two years of age due to poor quality of life.Learn More

Inguinal Cryptorchidism

Cryptorchidism, or the failure of one or both testes to descend into the scrotal sac during maturation, is the most common disorder of sex development in dogs, with a reported prevalence of 0.8–10%Learn More

May-Hegglin Anomaly

May-Hegglin Anomaly (MHA) is an inherited blood cell disorder characterized by abnormal platelets and white cells.Learn More

Microphthalmia

Microphthalmia is an inherited eye disease affecting dogs, including breeds such as ,Australian Cobberdog, Soft Coated Wheaten Terrier, characterized by underdeveloped eyes smaller than normal, often with malformations of the optic nerve and variable loss of vision.Learn More

Mitochondrial dysfunction syndrome 3 (MMDS3)

Mitochondrial dysfunction syndrome 3 (MMDS3) due to IBA57 is a rare genetic disorder caused by mutations in the IBA57 gene, leading to mitochondrial dysfunction, neurological impairment, and other systemic symptoms.Learn More

Mucopolysaccharidosis I (Boston Terrier Type)

Mucopolysaccharidosis I (MPS I) (Boston Terrier Type) is a severe genetic disorder that leads to enzyme deficiency affecting multiple body systems in dogs.Learn More

Mucopolysaccharidosis I (Plott Hound Type)

Mucopolysaccharidosis I (MPS I) in Plott Hounds is a genetic disorder that disrupts the breakdown of glycosaminoglycans, leading to severe systemic abnormalities.Learn More

Mucopolysaccharidosis IIIA (Dachshund Type)

Mucopolysaccharidosis IIIA (Dachshund Type) is a genetic lysosomal storage disorder in Dachshunds causing progressive neurological deterioration due to the buildup of heparan sulfate.Learn More

Mucopolysaccharidosis IIIA (New Zealand Huntaway Type)

Mucopolysaccharidosis IIIA (New Zealand Huntaway Type) is a genetic lysosomal storage disorder in New Zealand Huntaways causing rapid neurological deterioration due to the buildup of heparan sulfate.Learn More

Mucopolysaccharidosis IIIB (Schipperke Type)

Mucopolysaccharidosis IIIB (MPS IIIB) (Schipperke Type) is a progressive, inherited lysosomal storage disorder primarily affecting the nervous system of dogs.Learn More

Mucopolysaccharidosis VI (Miniature Schnauzer Type)

Mucopolysaccharidosis VI (MPS V1) (Miniature Schnauzer Type) is an inherited lysosomal storage disorder causing abnormal growth and function due to enzyme deficiency.Learn More

Mucopolysaccharidosis VII (Brazilian Terrier Type)

Mucopolysaccharidosis VII (MPS VII) (Brazilian Terrier Type) is an inherited lysosomal storage disorder in dogs, characterized by insufficient beta-glucuronidase activity, leading to severe skeletal abnormalities and early death.Learn More

Multifocal Retinopathy 1

Multifocal Retinopathy 1 is an inherited retinal disorder in dogs that causes multiple areas of retinal detachment, potentially leading to vision problems.Learn More

Multidrug Resistance 1

Multidrug Resistance 1 (MDR1) is a genetic condition in dogs that increases the risk of adverse reactions to certain medications.Learn More

Multifocal Retinopathy 2

Multifocal Retinopathy 2 is an inherited retinal disorder in dogs, causing multiple areas of retinal detachment that can potentially lead to vision issues.Learn More

Multifocal Retinopathy 3

Multifocal retinopathy 3 is an inherited disorder affecting dogs' retinas, causing circular areas of detachment with fluid accumulation visible during veterinary eye exams, typically appearing between 9 months and 2 years of age. These lesions vary in color, size, and location, occasionally presenting with retinal folding, but generally do not lead to significant vision loss. Learn More

Muscular Dystrophy (Cavalier King Charles Spaniel Type)

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Muscular Dystrophy (Golden Retriever Type)

Golden Retriever muscular dystrophy is an inherited X-linked recessive disorder that impairs the production of a protein essential for muscle contraction and relaxation, leading to symptoms such as muscle weakness, abnormal gait, excessive drooling, and muscle atrophy, often requiring hand feeding and resulting in variable prognosis depending on disease severity.Learn More

Muscular Dystrophy (Norfolk Terrier Type)

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Muscular Dystrophy, Ullrich Type (Landseer Type)

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Muscular Hypertrophy (Double Muscling)

Muscular hypertrophy is a condition that significantly impacts muscle growth in dogs. Normally, muscle growth is regulated by a gene that produces myostatin, a protein that inhibits excessive muscle development. A mutation in this gene results in decreased myostatin levels, leading to dogs with pronounced muscle mass and an athletic build.Learn More

Musladin-Lueke Syndrome

Musladin-Lueke Syndrome is an inherited disorder primarily affecting Beagles, marked by increased connective tissue in the skin and joints, resulting in unique physical characteristics and movement difficulties, with symptoms stabilizing by about one year of age. Learn More

Myeloperoxidase Deficiency (Italian Hound Type)

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Myotonia Congenita (Australian Cattle Dog Type)

Myotonia Congenita (MC) (Australian Cattle Dog Type) is an inherited muscle disorder causing persistent muscle contraction and stiffness in Australian Cattle Dogs.Learn More

Myotonia Congenita (Labrador Retriever Type)

Myotonia Congenita (MC) (Labrador Retriever Type) is an inherited muscle disorder causing stiffness and difficulty moving in Labrador Retrievers.Learn More

Myotonia Congenita (Schnauzer Type)

Myotonia Congenita (Schnauzer Type) is an inherited muscle disorder in dogs where muscles remain contracted, causing stiffness and a distinct gait.Learn More

Myotubular Myopathy 1 (Boykin Spaniel Type)

Myotubular Myopathy 1 (MTM1) (Boykin Spaniel Type) is an inherited, severe muscle disease that primarily affects male Boykin Spaniels.Learn More

Myotubular Myopathy 1 (Labrador Retriever Type)

Myotubular Myopathy 1 (MYM1) (Labrador Retriever Type) is an X-linked inherited muscle disease severely affecting Labrador Retrievers primarily in puppyhood. Learn More

Narcolepsy (Dachshund Type)

Narcolepsy (NA) (Dachshund Type) is an inherited sleep disorder in Dachshunds, characterized by excessive daytime sleepiness and sudden episodes of muscle weakness or collapse triggered by excitement.Learn More

Myotubular Myopathy 1 (Rottweiler Type)

Myotubular Myopathy 1 (MTM1) (Rottweiler Type) is a severe inherited muscle disease that primarily affects male Rottweilers, presenting early in puppyhood.Learn More

Narcolepsy (Doberman Pinscher Type)

Narcolepsy (NA) (Doberman Pinscher Type) is an inherited sleep disorder in Doberman Pinschers, characterized by excessive daytime sleepiness and sudden episodes of muscle weakness or collapse triggered by excitement. Learn More

Narcolepsy (Labrador Retriever Type)

Narcolepsy (NA) (Labrador Retriever Type) is an inherited sleep disorder in Labrador Retrievers, characterized by excessive daytime sleepiness and sudden episodes of muscle weakness or paralysis triggered by excitement.Learn More

Neonatal Ataxia

Neonatal Ataxia (NA), or Bandera's Syndrome (BNAt), is an early onset inherited neurological disorder in Coton de Tulears, affecting coordination and movement due to improper cerebellum function.Learn More

Neonatal Encephalopathy with Seizures

Neonatal Encephalopathy with Seizures (NEWS) is an inherited neurological disease in dogs that causes severe neurological symptoms and often leads to death by 7 weeks of age.Learn More

Neonatal Cerebellar Cortical Degeneration

Neonatal cerebellar cortical degeneration is an inherited neurological disorder in Beagles and Carlin pinschers, causing symptoms of uncoordinated movement and poor balance due to cell degeneration in the cerebellum, often leading to euthanasia due to lack of recovery.Learn More

Neuroaxonal Dystrophy

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Neuroaxonal Dystrophy (Giant Schnauzer Type)

Neuroaxonal Dystrophy (NAD) in Giant Schnauzers is a fatal inherited neuromuscular disorder characterized by severe motor nerve cell dysfunction leading to respiratory failure at birth.Learn More

Neuroaxonal Dystrophy (Papillon Type)

Neuroaxonal Dystrophy (NAD) in Papillons is a severe, inherited neurological disorder that leads to early-life paralysis and sensory deficits.Learn More

Neuroaxonal Dystrophy (Rottweiler Type)

Neuroaxonal Dystrophy (NAD) in Rottweilers is an inherited neurological disorder that causes uncoordinated movements and tremors due to nerve degeneration.Learn More

Neuroaxonal Dystrophy (Spanish Water Dog Type)

Neuroaxonal Dystrophy (NAD) in Spanish Water Dogs is a genetic neurological disorder characterized by abnormal gait, behavior changes, and progressive neurodegeneration, often leading to euthanasia within a year of diagnosis.Learn More

Neuronal Ceroid Lipofuscinosis (Tibetan Terrier Type)

Neuronal Ceroid Lipofuscinosis (Tibetan Terrier Type) is an inherited lysosomal storage disorder in dogs, characterized by a deficiency in a specific enzyme crucial for normal metabolism, leading to the accumulation of waste compounds in nervous system cells and causing progressive vision loss, neurological symptoms, and behavioral changes typically starting between 4 to 7 years of age, with no current treatment available. Learn More

Neurodegeneration w/ Alpha-Mannosidase Deficiency and Cytoplasmic Vacuoles

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Neuronal Ceroid Lipofuscinosis 1

Neuronal Ceroid Lipofuscinosis 1 (NCL1) is a devastating inherited lysosomal storage disease affecting the nervous system of dogs, particularly seen in Miniature Dachshunds. Learn More

Neuronal Ceroid Lipofuscinosis 1 (Cane Corso Type)

Neuronal Ceroid Lipofuscinosis 1 (NCL1) in Cane Corsos is a devastating inherited disorder characterized by a progressive decline in neurological function due to enzyme deficiency. Learn More

Neuronal Ceroid Lipofuscinosis 12

Neuronal Ceroid Lipofuscinosis 12 is an inherited lysosomal storage disease affecting dogs, particularly Australian Cattle Dog, Australian Stumpy Tail Cattle Dog, Miniature Australian Cattle Dog, causing progressive neurological symptoms such as abnormal gait, anxiety, seizures, and vision loss, typically appearing around 6 years of age.Learn More

Neuronal Ceroid Lipofuscinosis 2

Neuronal Ceroid Lipofuscinosis 2 (NCL2) is an inherited, rapidly progressing neurological disease in dogs, leading to severe mental and physical impairments and early death.Learn More

Neuronal Ceroid Lipofuscinosis 10

Neuronal ceroid lipofuscinosis 10 (NCL10) is a hereditary lysosomal storage disease in dog breeds such as, American Bulldog andAmerican Bully, this is caused by a deficiency in the enzyme cathepsin D, leading to the accumulation of proteins in cells and resulting in progressive neurological symptoms such as lack of muscle coordination and difficulty balancing, typically appearing between 1 to 3 years of age and often leading to euthanasia within two years of diagnosis.Learn More

Neuronal Ceroid Lipofuscinosis 4A

Neuronal Ceroid Lipofuscinosis 4A (NCL4A) is an adult-onset lysosomal storage disease affecting dogs' brain and nervous system functions.Learn More

Neuronal Ceroid Lipofuscinosis 5 (Golden Retriever Type)

Neuronal Ceroid Lipofuscinosis 5 (Golden Retriever Type) is a genetic lysosomal storage disease causing severe neurological symptoms and early death in affected dogs.Learn More

Neuronal Ceroid Lipofuscinosis 5 (Herding Dog Type)

Neuronal Ceroid Lipofuscinosis 5 (Herding Dog Type) is an inherited lysosomal storage disease that causes severe neurological degeneration in affected dogs.Learn More

Neuronal Ceroid Lipofuscinosis 6

Neuronal Ceroid Lipofuscinosis 6 (NCL6) is a genetic lysosomal storage disease that causes severe neurological symptoms and early death in affected dogs.Learn More

Neuronal Ceroid Lipofuscinosis 7

Neuronal Ceroid Lipofuscinosis 7 (NCL7) is a fatal genetic disorder in dogs that leads to severe neurological degradation and early death.Learn More

Recurrent Inflammatory Pulmonary Disease

Recurrent Inflammatory Pulmonary Disease is an inherited disorder affecting dogs such as Collie, Rough Collie, Smooth Collie, characterized by early-life onset of respiratory symptoms such as coughing, nasal discharge, fever, vomiting, and noisy breathing.Learn More

Renal Cystadenocarcinoma and Nodular Dermatofibrosis

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND) is an inherited genetic disorder in dogs that predisposes them to kidney, skin, and uterine cancers.Learn More

Retinal Dysplasia/Oculoskeletal Dysplasia 1

Retinal Dysplasia/Oculoskeletal Dysplasia 1 is an inherited disorder in dogs causing eye abnormalities and dwarfism. in breeds such as Australian Labradoodle, Lab/Golden Cross, Labradoodle, Labrador Retriever, Service/Assistance Lab/Golden Retriever cross, Service/Assistance Labrador Retriever, UK Breed Council Labrador Retriever.Learn More

Retinal Dysplasia/Oculoskeletal Dysplasia 2

Retinal dysplasia/oculoskeletal dysplasia 2 is an inherited collagen disorder affecting breeds such as Samoyeds, characterized by dwarfism with curved forelimbs, a domed head, and eye abnormalities like retinal detachment and cataracts, and is inherited in an autosomal incomplete dominant manner, making genetic testing vital for responsible breeding practices. Learn More

Sensory Neuropathy (Border Collie Type)

Sensory Neuropathy (Border Collie Type) is a progressive neurological disease in dogs, typically presenting between two and seven months of age with symptoms such as ataxia, abnormal gait, muscle atrophy, and loss of limb sensation, often leading to euthanasia within 18 months due to impaired quality of life. Learn More

Severe Combined Immunodeficiency Disease (Terrier Type)

Severe Combined Immunodeficiency Disease (SCID) in Terriers is a fatal genetic disorder that impairs immune function, leaving affected dogs highly susceptible to infections.Learn More

Severe Combined Immunodeficiency Disease (Wetterhoun Type)

Severe Combined Immunodeficiency Disease (SCID) (Wetterhoun Type) is a fatal inherited condition in Wetterhouns, characterized by the inability to develop a functional immune system, leading to severe infections and early death.Learn More

Shar-Pei Autoinflammatory Disease

Shar-Pei Autoinflammatory Disease (SPAID) is a genetically inherited disorder characterized by episodes of fever and joint swelling in Shar-Pei dogs. Learn More

Skeletal Dysplasia 2

Skeletal Dysplasia 2 (SD2) is an inherited musculoskeletal disorder in Labrador Retrievers that causes mild disproportionate dwarfism with short legs and normal body proportions.Learn More

Spinocerebellar Ataxia (Alpine Dachsbrake Type)

Spinocerebellar Ataxia (SA) (Alpine Dachsbrake Type) is an inherited neurological disorder in dogs characterized by severe motor coordination deficits manifesting shortly after birth.Learn More

Spinal Dysraphism

Spinal Dysraphism (SD) is an inherited condition in dogs characterized by abnormal spinal cord development that leads to neurological impairments.Learn More

Spinocerebellar Ataxia (Terrier Type)

Spinocerebellar Ataxia (Terrier Type) is an early-onset, inherited neurological disorder affecting dogs, observed in various breeds such as Basenji, Chihuahua, Jack Russell Terrier, Parson Russell Terrier, Russell Terrier, Smooth Fox Terrier, Tenterfield Terrier, Toy Fox Terrier, Wire Fox Terrier, presenting with symptoms of incoordination, loss of balance, and a progressive "prancing" gait, often leading to falls, muscle twitching, and rigidity resembling seizures, ultimately resulting in euthanasia due to a diminished quality of life.Learn More

Spondylocostal Dysostosis

Spondylocostal Dysostosis (SCD) is an inherited skeletal disorder in dogs, causing severe spinal and rib abnormalities, often resulting in death shortly after birth.Learn More

Stargardt Disease

Stargardt Disease is an inherited eye disorder in dogs that leads to progressive vision loss.Learn More

Startle Disease

Startle Disease, or hyperekplexia, is a genetic neurological disorder in Irish Wolfhounds that causes severe muscle rigidity and tremors when handled, often leading to early euthanasia due to poor quality of life.Learn More

Subacute Necrotizing Encephalopathy (Yorkshire Terrier Type)

Subacute Necrotizing Encephalopathy (Yorkshire Terrier Type) is a genetic neurological disorder in dogs causing progressive brain damage due to impaired thiamine transport, leading to severe neurological symptoms and early euthanasia.Learn More

Thrombopathia (American Eskimo Dog Type)

Thrombopathia (TBP) (American Eskimo Dog Type) is an inherited bleeding disorder in American Eskimo dogs characterized by defective platelet function leading to excessive bleeding. Learn More

Thrombopathia (Newfoundland Type)

Thrombopathia (TBP) (Newfoundland Type) is an inherited blood clotting disorder in Newfoundland dogs, characterized by defective platelet function leading to excessive and spontaneous bleeding. Learn More

Thrombopathia (Basset Hound Type)

Thrombopathia (TBP) (Basset Hound Type) is an inherited bleeding disorder in Basset Hounds characterized by impaired platelet function leading to increased and spontaneous bleeding.Learn More

Trapped Neutrophil Syndrome

Trapped Neutrophil Syndrome (TNS) in Border Collies is a genetic disorder that impairs the immune system's ability to fight infections, leading to severe health problems and often early death.Learn More

Ullrich Congenital Muscular Dystrophy (Labrador Retriever Type 1)

Ullrich Congenital Muscular Dystrophy (Labrador Retriever Type 1) is a hereditary muscle disorder in dogs that causes limb deformities, joint hyperflexion, and progressive muscle weakness, leading to an abnormal gait and potential long-term health issues. Learn More

Ullrich Congenital Muscular Dystrophy (Labrador Retriever Type 2)

Ullrich Congenital Muscular Dystrophy (Labrador Retriever Type 2) is a genetic disorder characterized by limb deformities and joint hyperflexion in Labrador Retrievers, caused by mutations in the COL6A3 gene.Learn More

Urolithiasis (Native American Indian Dog Type)

Urolithiasis (Native American Indian Dog Type) is an inherited condition causing urinary stones due to elevated levels of 2,8-dihydroxyadenine in dogs.Learn More

Van Den Ende-Gupta Syndrome

Van Den Ende-Gupta Syndrome (VDEGS) is an inherited skeletal disorder in dogs, characterized by distinct skeletal abnormalities including an underbite and bowed legs.Learn More

Von Willebrand Disease I

Von Willebrand Disease I (vWD I) is an inherited bleeding disorder in dogs caused by a deficiency of the von Willebrand factor, which is crucial for blood clotting.Learn More

Von Willebrand Disease II

Von Willebrand Disease II (vWDII) in dogs is an inherited bleeding disorder that results in reduced and abnormal von Willebrand factor levels, leading to moderate to severe bleeding problems.Learn More

Von Willebrand Disease III (Kooikerhondje Type)

Von Willebrand Disease III (vWDIII) in Kooikerhondjes is an inherited bleeding disorder characterized by extremely low levels of von Willebrand factor, critical for blood clotting.Learn More

Von Willebrand Disease III (Scottish Terrier Type)

Von Willebrand Disease III (vWDIII) in Scottish Terriers is an inherited bleeding disorder characterized by extremely low levels of von Willebrand factor, leading to severe bleeding risks.Learn More

X-Linked Hereditary Nephropathy (Navasota Dog Type)

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Von Willebrand Disease III (Shetland Sheepdog Type)

Von Willebrand Disease III (vWDIII) in Shetland Sheepdogs is an inherited bleeding disorder marked by extremely low levels of von Willebrand factor, leading to significant bleeding risks.Learn More

X-Linked Severe Combined Immunodeficiency Disease (Basset Hound Type)

X-linked Severe Combined Immunodeficiency (XSCID) in Basset Hounds is a fatal inherited condition characterized by a profound deficiency in immune function.Learn More

X-Linked Severe Combined Immunodeficiency Disease (Corgi Type)

X-linked Severe Combined Immunodeficiency (XSCID) in Corgis is a fatal genetic disorder characterized by a critical failure in immune system function.Learn More

X-Linked Tremors (English Springer Spaniel Type)

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Xanthinuria, Type 1 (Mixed breed Type)

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Xanthinuria, Type II (Cavalier King Charles Spaniel Type)

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Xanthinuria, Type II (Toy Manchester Terrier Type)

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Obesity (in Labrador Retrievers)

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X-linked retinal dysplasia (English cocker spaniel)

X-linked retinal dysplasia in English Cocker Spaniels, caused by mutations in the NDP gene, leads to progressive vision loss due to abnormal retinal development.Learn More

XX Disorder of Sex Development

XX Disorder of Sex Development is a rare genetic condition where individuals with two X chromosomes experience atypical sexual development due to mutations in the BTBD17 gene, leading to ambiguous or male-like physical characteristics.Learn More

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