Body size
Affected Genes: multiple
Inheritance: Complex Inheritance
Variant(canFam6):
GHR chr4:66722531: C>T
GHR chr4:66722572: G>A
IGF1 chr15:41589446: G>A
IGF1 chr15:41588984-41588985: insertion SINE
IGF1R chr3:44548772: G>A
IGF2BP2 chr34:22491869: G>A
SMAD2 chr7:43278847-43288795: 9.9 kb deletion
STC2 chr4:39129435: A>T
General Information: Canine body size refers to the physical dimensions and weight of dogs, which can vary widely among different breeds and individual animals. Factors such as genetics, breed standards, nutrition, and overall health influence canine body size. The diversity in body sizes seen in dogs today is a result of different breeds being developed to fulfill specific roles and functions.
References:
Rimbault M, Beale HC, Schoenebeck JJ, Hoopes BC, Allen JJ, Kilroy-Glynn P, Wayne RK, Sutter NB, and Ostrander EA. Derived variants at six genes explain nearly half of size reduction in dog breeds. Genome Res. 2013 23(12): 1985–1995.
Heinrich J, Berger C, Berger B, Hecht W, Phillips C, Parson W. The LASSIE MPS panel: Predicting externally visible traits in dogs for forensic purposes. Forensic Science International: Genetics 2023 66:102893.
Plassais J, Kim J, Davis BW, Karyadi DM, Hogan AN, Harris AC, Decker B, Parker HG, and Ostrander EA. Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology. Nat Commun. 2019 10(1):1489.