Canine Scott Syndrome
Affected Genes: ANO6
Inheritance: Autosomal Recessive
Variant(canFam6):
chr27:37401244: G>A
Breed: Beagle
Chinese Crested
German Shepherd Dog
Shiloh Shepherd
White Shepherd Dog
General Information: Canine Scott Syndrome (CSS) is an inherited disorder affecting dogs, characterized by defective platelets that lead to inadequate blood clotting at sites of tissue damage. Dogs with this condition often experience excessive bruising and bleeding following surgeries, dental procedures, or traumatic events. Additionally, affected dogs may suffer from spontaneous bleeding episodes, such as severe nosebleeds, joint bleeding, and excessive bleeding during teething. Due to these bleeding risks, veterinarians should have blood ready for transfusions when performing surgery on affected dogs. This disorder requires careful management to prevent and treat bleeding complications effectively.
How to Read Your Dog's Test Results for this Genetic Variant:
Two Variants Detected: Dog Likely Affected
One Variant Detected: Dog Unlikely Affected
No Variants Detected: No Effect
Gene / Testing Information: Genetic testing of the ANO6 gene can indicate the presence of variants for Canine Scott Syndrome (CSS). This autosomal recessive disorder requires two copies of the mutated gene for a dog to be affected. Carrier dogs typically do not show symptoms, but breeding two carriers can produce affected pups, with each pup having a 25% chance of developing the disease. Genetic testing is essential for informed breeding practices to prevent the mutation. Breeding of two carrier dogs is not recommended.Non-carrier dogs have no increased risk of producing affected pups from this known variant.
References:
Brooks MB, Catalfamo JL, MacNguyen R, Tim D, Fancher S, McCardle JA. A TMEM16F Point Mutation Causes an Absence of Canine Platelet TMEM16F and Ineffective Activation and Death-Induced Phospholipid Scrambling. J Thromb Haemost. 2015 13(12):2240-2252.
Jandrey KE, Norris JW, Tucker M, Brooks MB. Clinical Characterization of Canine Platelet Procoagulant Deficiency (Scott Syndrome). J Vet Intern Med. 2012 26(6):1402-1407.