Chondrodystrophy (CDDY and IVDD Risk) with or without Chondrodysplasia (CDPA)

General Information: Chondrodystrophy (CDDY) with or without Chondrodysplasia (CDPA) is a genetic disorder in dogs characterized by the development of short limbs and an elevated risk of intervertebral disc disease (IVDD). This condition arises due to mutations in the FGF4 gene on chromosomes 12 and 18, resulting in premature degeneration and calcification of the intervertebral discs and the bones, respectively. Dogs with CDDY are prone to back pain, difficulty walking, and in severe cases, paralysis due to disc herniation that compresses the spinal cord. Chondrodysplasia (CDPA) specifically causes short, curved limbs commonly seen in breeds like Dachshunds and Basset Hounds. Symptoms of these conditions can include a distinctive gait, back pain, reluctance to move, and, in advanced cases, neurological deficits.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Possibly Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for Chondrodystrophy (CDDY) and Chondrodysplasia (CDPA) focuses on identifying specific mutations in the FGF4 gene on chromosomes 12 and 18. The mutation on chromosome 12 is linked to both shortened limbs and an increased risk of IVDD, while the mutation on chromosome 18 is associated with the short-legged phenotype but not with IVDD. These conditions are inherited in an autosomal dominant manner, meaning that dogs with one copy of the mutated gene are at increased risk, and those with two copies may have more severe phenotypes. Genetic testing is crucial for breeding decisions to avoid pairing dogs that carry these mutations, thereby reducing the risk of producing offspring with severe IVDD or disproportionate dwarfism. By utilizing genetic information, breeders can maintain desired breed characteristics, like short limbs, while minimizing the health risks associated with these mutations.