Gallbladder Mucoceles

General Information: Gallbladder Mucoceles (GBM) is a condition where the gallbladder fills with a thick, mucus-like bile that can obstruct the bile ducts. This condition is especially common in certain dog breeds, including Shetland Sheepdogs, Miniature Schnauzers, and Cocker Spaniels. Dogs affected by GBM may show symptoms such as vomiting, loss of appetite, abdominal pain, jaundice (yellowing of the skin and eyes), and lethargy. In severe cases, the gallbladder can rupture, leading to a life-threatening situation. Early detection and treatment are critical for managing this condition and preventing serious complications.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Possibly Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for the ABCB4 gene mutation associated with Gallbladder Mucoceles can identify dogs at risk for developing this condition. The mutation is inherited in an Autosomal Dominant manner with Incomplete Penetrance, meaning dogs with one copy of the mutated gene are at increased risk. When breeding, it's crucial to avoid pairing dogs that carry the mutation to prevent producing affected offspring. While genetic testing helps in identifying carriers, environmental factors may also influence disease expression. Regular testing before breeding ensures informed decisions to maintain healthy breeding lines and reduce the incidence of Gallbladder Mucoceles.