Greyhound Polyneuropathy

General Information: Greyhound Polyneuropathy (GP) presents as a progressive neurological disorder in Greyhounds, typically becoming apparent between three to nine months of age. The initial symptoms include exercise intolerance and a distinctive "bunny-hopping" gait. As the disease progresses, affected dogs develop severe muscle wasting and ataxia. Additional symptoms may include a change or loss of bark, noisy breathing, and difficulties with respiration. The progression of GP often leads to severe complications such as respiratory failure. Unfortunately, due to the rapid progression and severity of symptoms, affected dogs are often humanely euthanized within the first year of life for welfare reasons.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for Greyhound Polyneuropathy (GP) involves analyzing the NDRG1 gene to identify carriers of the disorder. GP is inherited in an autosomal recessive pattern, which means that a dog must inherit two copies of the mutated gene (one from each parent) to express the disease. Carriers, who have only one copy of the mutated gene, typically show no symptoms but have a 50% chance of passing the mutation to their offspring. Breeding two carriers results in a 25% chance that each offspring will be affected by GP. Responsible breeding practices, guided by reliable genetic testing, are crucial to minimize the transmission of this mutation. It is recommended that carriers are not bred together to prevent the birth of affected puppies. Dogs not carrying the mutation are not at risk of developing or transmitting GP. Genetic testing is an essential tool in managing the breeding of Greyhounds to ensure healthier future generations.