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Hairlessness

Hairlessness is a genetic condition in dogs, particularly affecting the American Hairless Terrier, caused by a mutation in the SGK3 gene, leading to the absence of hair.

Affected Genes: SGK3

Variant(canFam6):
rh1=chr29:16682551-16682554: 4 bp deletion TTAG
rh2=chr29:16667839-16667840: 1 bp insertion T

Breed: Chinese Crested
Mexican Hairless Dog
Peruvian Hairless Dog

Genetic testing of the SGK3 gene can determine whether a dog is a genetic carrier of the hairlessness trait. Hairlessness is inherited in an autosomal recessive manner, meaning that a dog must inherit two copies of the mutated gene (one from each parent) to exhibit the hairless phenotype. Dogs that inherit only one copy of the mutated gene are carriers and do not show signs of hairlessness, but they can pass the mutation to their offspring. When two carriers are bred, each puppy has a 25% chance of being hairless and a 50% chance of being a carrier of the mutation. Reliable genetic testing is crucial for breeders to identify carriers and manage breeding programs effectively to avoid producing puppies with hairlessness, unless that is a desired trait. Ensuring informed breeding practices helps maintain the health and welfare of both the parents and offspring in breeding lines. It is also important to recognize that the presence of the hairlessness gene does not exclude the potential for other genetic conditions that may require additional genetic screening.

References:
Hytönen MK, Lohi H. A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate gene for human alopecia conditions. Hum Genet. 2019 138, 535–539.

Parker HG, Harris A, Dreger DL, Davis BW, Ostrander EA. 2017 The bald and the beautiful: hairlessness in domestic dog breeds. Phil. Trans. R. Soc. B 372: 20150488.