Hereditary Footpad Hyperkeratosis (Irish Terrier and Kromfohrländer type)

General Information: Hereditary Footpad Hyperkeratosis (HFH) is a genetic condition affecting dogs, characterized by the abnormal thickening and hardening of the footpads. Symptoms typically appear between 4 to 6 months of age, with affected dogs developing hard, thickened footpads that often crack deeply over time. These cracks can lead to foot infections, significant pain, and lameness. Additionally, thick, horny growths may form around the rims of the footpads, and the toenails of affected dogs tend to be harder and grow faster than normal. Some dogs may also exhibit a duller and softer hair coat compared to their littermates. This condition can severely impact the dog's mobility and overall quality of life.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for Hereditary Footpad Hyperkeratosis (HFH) involves screening for mutations in the FAM83G gene to determine carrier status. HFH is inherited in an autosomal recessive manner, meaning a dog must inherit two copies of the mutated gene, one from each parent, to develop the disease. Carriers, which have only one copy of the mutation, do not typically show symptoms but can pass the mutation to their offspring. When two carriers are bred, each puppy has a 25% chance of being affected and a 50% chance of being a carrier. To prevent producing affected puppies and eliminate the mutation from breeding lines, it is crucial to avoid breeding two carriers. Genetic testing is essential for responsible breeding practices, ensuring that dogs that are not carriers of the mutation do not pose a risk of producing affected puppies.