Hereditary Nasal Parakeratosis (Labrador Retriever Type)

General Information: Hereditary Nasal Parakeratosis (HNP) is an inherited condition that primarily affects the noses of Labrador Retrievers, typically beginning to manifest between 6 and 12 months of age. Dogs with HNP develop dry, rough, gray to brown crusts on the tip of the nose, which can occasionally lead to painful cracks. In some cases, these crusty lesions extend to the haired skin surrounding the nose. Affected noses are also more susceptible to superficial bacterial infections and may lose pigmentation over time. While dogs with HNP are otherwise healthy, the condition requires ongoing management with topical therapies to prevent recurrent crusting and maintain nasal health. The severity of symptoms can vary throughout the dog's life, and although the condition is manageable, it necessitates consistent care to alleviate discomfort and prevent complications.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for the SUV39H2 gene is essential for identifying carriers of the mutation responsible for Hereditary Nasal Parakeratosis (HNP) in Labrador Retrievers. This disorder is inherited in an autosomal recessive manner, meaning a dog must inherit two copies of the mutated gene, one from each parent, to develop the disease. Dogs carrying only one copy of the mutation (carriers) typically do not exhibit any symptoms but can pass the gene to their offspring. When two carriers are bred, each puppy has a 25% chance of being affected by HNP and a 50% chance of being a carrier. Reliable genetic testing is crucial for responsible breeding practices to avoid mating two carriers, thereby reducing the risk of producing puppies with this nasal condition. By ensuring that only non-carrier dogs are bred, breeders can help eliminate HNP from Labrador Retriever lines, promoting healthier future generations and maintaining the quality and health of the breed.