Hyperuricosuria

General Information: Hyperuricosuria is a genetic urinary condition affecting numerous dog breeds, including Airedale Terriers, French Bulldogs, German Shepherds, and Labrador Retrievers. This disorder is caused by mutations in the SLC2A9 gene, which encodes a protein responsible for transporting uric acid from the urine. Dogs with mutations in both copies of this gene cannot effectively reabsorb uric acid, leading to high concentrations in the urine. This excess uric acid can form crystals and stones (uroliths) in the urinary tract, leading to symptoms such as frequent urination, blood in the urine, straining to urinate, loss of appetite, lethargy, vomiting, and pain. Male dogs are more susceptible to urinary obstructions due to anatomical differences, though both males and females can be affected. If left untreated, hyperuricosuria can lead to recurrent urinary tract infections, kidney failure, and potentially fatal urinary blockages. Early diagnosis and management, including dietary modifications and regular veterinary monitoring, are essential to prevent severe complications and ensure the health and well-being of affected dogs.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for the SLC2A9 gene is crucial for identifying carriers of the mutation responsible for Hyperuricosuria in dogs. This condition is inherited in an autosomal recessive manner, meaning that a dog must inherit two copies of the mutated gene, one from each parent, to develop the disease. Carrier dogs, which have only one copy of the mutation, typically do not exhibit symptoms but can pass the gene to their offspring. When two carriers are bred, each puppy has a 25% chance of developing hyperuricosuria and a 50% chance of being a carrier. Reliable genetic testing is vital for responsible breeding practices to avoid mating two carriers, thereby reducing the risk of producing puppies with hyperuricosuria. By identifying carriers and making informed breeding decisions, breeders can help eliminate this condition from dog populations, promoting healthier and more robust future generations. It is important to note that while genetic testing for the SLC2A9 mutation can reduce the risk of hyperuricosuria, other genetic or environmental factors may still contribute to similar urinary conditions, necessitating comprehensive genetic screening and careful management.