Ichthyosis (Golden Retriever Type 2)

General Information: Ichthyosis (Golden Retriever Type 2) affects dogs with variable onset and severity, commonly showing up as flaky skin and lackluster hair early on. As the condition advances, the skin thickens, becomes scaly—particularly noticeable on the abdomen—and may vary in intensity throughout the dog’s life. While most affected dogs manage well, they are prone to skin infections due to compromised skin barrier function.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for Ichthyosis (Golden Retriever Type 2) targets the ABHD5 gene to identify carriers. This condition follows an autosomal recessive pattern, meaning dogs need two copies of the mutated gene (one from each parent) to exhibit symptoms. Carriers, with one normal and one mutated gene, do not show signs of the disease but can pass on the mutation. Breeding two carriers increases the risk of affected offspring. Therefore, genetic testing is essential before breeding to prevent transmitting this genetic disorder. Clear results (normal genotype) indicate no risk, while carriers should be bred carefully to avoid producing affected pups.