Myeloperoxidase Deficiency (Italian Hound Type)

General Information: Myeloperoxidase Deficiency (Italian Hound Type) is an inherited disorder in dogs characterized by a deficiency in the enzyme myeloperoxidase, which plays a critical role in the immune system's ability to fight off infections. This condition results from a genetic mutation that affects the production or function of the enzyme, leading to an increased susceptibility to bacterial infections. Dogs with two copies of the associated gene mutation are predisposed to Myeloperoxidase Deficiency, which can manifest at any age. Symptoms include recurrent infections, slow healing of wounds, lethargy, and weakness. While not all dogs with the mutation will show symptoms, those affected may require regular veterinary care and management to prevent and treat infections. Early diagnosis and supportive care are essential to managing the condition and maintaining the dog's health.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing of the specific gene associated with Myeloperoxidase Deficiency (Italian Hound Type) can determine if a dog is a carrier of this condition. This disorder is inherited in an Autosomal Recessive manner, meaning that dogs must inherit two copies of the mutated gene, one from each parent, to develop the disease. Carrier dogs, possessing only one copy of the mutation, typically do not show symptoms but can pass the gene to their offspring. When two carriers are bred, each pup has a 25% chance of developing the disease and a 50% chance of being a carrier. Reliable genetic testing is crucial for informed breeding practices to eliminate this mutation from breeding lines, and breeding two carriers together is not recommended to avoid producing affected pups. Dogs that are not carriers have no increased risk of having affected offspring.