Primary Open Angle Glaucoma and Primary Lens Luxation (Shar Pei Type)

General Information: POAG Shar-Pei Type is an inherited eye condition affecting Shar Pei dogs, typically manifesting before 6 years of age. It initially causes subtle symptoms like increased eye pressure, which can lead to eye enlargement and eventually vision loss. Dogs may also experience lens displacement, exacerbating the condition.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing of the ADAMTS17 gene identifies dogs as carriers of the POAG Shar-Pei Type mutation. This condition follows an Autosomal Recessive inheritance pattern, requiring two copies of the mutated gene (one from each parent) for a dog to develop the disease. Carriers themselves do not show symptoms, but breeding two carriers increases the risk of producing affected offspring. Testing before breeding helps avoid this risk, as affected dogs may not show symptoms until adulthood. Breeding practices should aim to eliminate the mutation by avoiding carrier-to-carrier pairings, ensuring healthier offspring.