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Shedding (SD Locus)

The SD Locus (SD) influences shedding levels in dogs through genetic variations in the MC5R and RSPO2 genes.

Affected Genes: MC5R

Inheritance: Complex Inheritance

Variant(canFam6):
chr1:25411744: T>C

Genetic testing for the SD Locus (SD) identifies variations in the MC5R and RSPO2 genes that affect a dog's shedding level. This trait is inherited in an autosomal incomplete dominant manner, meaning a single copy of the high-shedding variant (SD) can result in increased shedding. Dogs with one copy of the variant (sd/SD) typically show moderate shedding, while those with two copies (SD/SD) may shed more heavily, and those without any copies (sd/sd) are characterized by low shedding. When planning breeding, it is beneficial to test potential sires and dams to predict the shedding characteristics of their offspring. By selecting appropriate mates, breeders can manage the shedding trait among puppies, potentially catering to specific owner preferences or lifestyle needs. It's also advisable to test for the IC locus, as it has been linked to shedding traits, to provide a comprehensive genetic shedding profile.

References:
Hayward JJ, Castelhano MG, Oliveira KC, Corey E, Balkman C, Baxter TL, Casal ML, Center SA, Fang M, Garrison SJ, Kalla SE, Korniliev P, Kotlikoff MI, Moise NS, Shannon LM, Simpson KW, Sutter NB, Todhunter RJ, Boyko AR. Complex disease and phenotype mapping in the domestic dog. Nat Commun 2016 7:10460.