X-Linked Hereditary Nephropathy (Navasota Dog Type)

General Information: X-Linked Hereditary Nephropathy (Navasota Dog Type) is an inherited disorder in dogs characterized by progressive kidney disease caused by a mutation on the X chromosome. This condition primarily affects male dogs, as they have only one X chromosome and therefore one copy of the mutated gene leads to the disease. Female dogs can be carriers of the mutation but typically do not show symptoms because they have a second, normal copy of the X chromosome. Symptoms in affected dogs include excessive thirst and urination, blood in the urine, vomiting, weight loss, and lethargy. As the disease progresses, it can lead to chronic kidney failure and significantly reduce the dog’s quality of life and lifespan. Early detection and supportive care can help manage the condition, but there is no cure.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing of the gene associated with X-Linked Hereditary Nephropathy (Navasota Dog Type) can determine if a dog is a carrier of this condition. This disorder is inherited in an X-linked manner, meaning that male dogs with one copy of the mutated gene will develop the disease, while female dogs with one copy will be carriers. Female carriers typically do not show symptoms but can pass the gene to their offspring. When a carrier female is bred, each pup has a 50% chance of inheriting the mutated gene. Male pups that inherit the gene will develop the disease, while female pups that inherit the gene will be carriers. Reliable genetic testing is crucial for informed breeding practices to reduce the prevalence of this mutation in breeding lines. Breeding carrier females to non-carrier males is recommended to avoid producing affected male pups. Dogs that are not carriers have no increased risk of having affected offspring.